Advantages
- Delivers localized Reactive Oxygen Species (ROS) exactly where antimicrobial activity is needed, allowing for targeted, antibiotic-free treatment with limited concerns of toxicity and inflammation.
- Prevents resistant bacteria, viruses, and biofilms without adding to antibiotic resistance.
- Multiple stimuli activation such as light, ultrasound, air flow, movement, mechanical stress, piezoelectric energy
- Noninvasive treatment for middle-ear infections, wounds, and other deep-tissue infection sites
- Offers durable, stimuli-responsive antimicrobial coatings that prevent contamination of medical implants, catheters, filters, masks, and surfaces.
- Suitable for a wide range of treatment formats including middle ear infection therapy, wound dressings, sprays, HVAC filters
- Integrated fluorescent components, providing additional potential for pathogen tracking, imaging, and treatment monitoring.
Summary
Drug-resistant infections, widespread pediatric infections such as otitis media, contaminated wounds, implant-associated infections, and airborne pathogens continue to place increasing pressure on healthcare systems. Conventional antibiotics tend to be less effective, may have systemic side effects and often do not provide targeted therapy at the site of infection. Therefore, there is a need for a flexible antibiotic-free solution for on-demand control of pathogens, while enabling safer, localized care.
A multifunctional nanoplatform with surface-stabilized metallic and semiconductor nanoparticles, fluorescent, polymer-composite, and piezoelectric elements in a single flexible system. When stimulated by light, ultrasound, airflow, movement, or mechanical stress, it generates localized Reactive Oxygen Species (ROS) that neutralize pathogens and disrupt biofilms. Its modular design can be easily converted into sprays, gels, dressings, filters and protective coatings for middle-ear infections, wound care, air purification, implant and catheter protection and targeted pathogen tracking in biomedical and environmental applications.
Image Description: Fig. 1. Multifunctional Stimuli-Activated Nanoplatform for Targeted ROS Therapy, Infection Control, and Environmental Protection.
Desired Partnerships
- License
- Sponsored Research
- Co-Development