Advantages
- Composition-Independent Thrombus Ablation
- Minimized Embolism Risk
- Reduced Procedure Time
- Compact and Affordable Design
- Safe for Vessel Walls
Summary
Thromboembolic conditions such as ischemic stroke, pulmonary embolism, and deep vein thrombosis continue to be major global health threats, often leading to severe disability or death. These emergencies are caused by blood clots (thrombi) that block critical blood flow in major arteries or veins. While mechanical and chemical thrombectomy techniques exist, they fall short especially when facing clots of complex or variable composition. Many patients require repeated device passes, which delay treatment, increase the risk of secondary emboli, and raise the likelihood of vessel injury or blood loss due to the use of larger catheters.
To address these shortcomings, this technology introduces a next-generation solution: Laser-Assisted Aspiration Thrombectomy (LAAT). This novel catheter combines a pulsed diode laser fiber with an aspiration system, enabling simultaneous ablation and removal of blood clots regardless of their composition. The laser gently breaks down thrombi without the need for aggressive mechanical force, reducing the risk of secondary embolism. Preliminary ex-vivo experiments using sheep blood clots of varying compositions have demonstrated the device’s ability to ablate both RBC-rich and fibrin-rich thrombi with controlled, pulsed laser exposures supporting its effectiveness and safety. Integrated aspiration then removes debris immediately at the source, lowering the chance of downstream occlusions. Unlike bulky crystal-based laser systems, our diode-laser design is compact, versatile in wavelength, and cost-efficient, making it practical for widespread clinical use.
Operational Overview of the Laser-Assisted Aspiration Thrombectomy System
Desired Partnerships
- License
- Sponsored Research
- Co-Development