Advantages:
- R/S 1,3-butanediol diacetoacetate clinically demonstrated superior weight loss compared to standard rodent chow or ketogenic diet
- Long-lasting weight maintenance suggests metabolic adaptations compared to typical diet-based approaches
- Scalable and cost-effective single-agent solution, offering a financial advantage over existing options
Summary:
Achieving sustainable weight loss remains a formidable challenge, with up to 95% of individuals regaining lost weight over time. Traditional dietary strategies, such as calorie restriction or macronutrient adjustments, can produce short-term results but often fail to prevent weight regain, partly due to metabolic adaptations and limited long-term adherence. Pharmacological and supplementation approaches, including various ketone-based and ketogenic regimens, offer potential benefits in augmenting metabolic efficiency and reducing adipose tissue; however, tolerance issues, restrictive dietary requirements, and diminished effects post-intervention continue to hinder their broader impact. These limitations underscore the need for more durable solutions that support lasting metabolic changes and simplify the path to sustained weight management beyond initial treatment periods.
R/S 1,3-butanediol diacetoacetate is a ketone ester that consistently reduces body weight and white adipose tissue in rodent models, outperforming other ketogenic agents such as BHB-salt and BHB-salt + MCT mixtures. In both acute and chronic administration studies, it not only induces weight loss but also sustains it after treatment cessation, suggesting lasting metabolic adaptations that address the critical long-term maintenance gap where most weight loss interventions fail. By demonstrating efficacy across multiple dosages (up to 25 g/kg/day) in both mice and rats and showing voluntary calorie restriction effects, the compound offers a novel, more durable weight management solution compared to standard ketogenic diets and supplements. Its key technical innovation lies in fostering metabolic changes that support ongoing weight control, rather than relying solely on continuous use or temporary dieting measures.
Ketone Ester (KE) induced and maintained long-term weight loss in VM/Dk mice compared to standard rodent chow (SD) and ketogenic diet (KD).
Desired Partnership:
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