Treatment of Traumatic Brain Injury Using Adipocyte Derived Stem Cells Secreting Long Noncoding RNAs, NEAT1 and MALAT1, or ADSC Conditioned Media

Tech ID: 13B194

­Competitive Advantages

  • Improved cognitive performance
  • Improved motor skills
  • Prevents cortical and hippocampal damage

Summary

USF researchers have shown that lncRNAs secreted from adipocyte derived stem cells (ADSC) can improve certain motor, cognitive, and histological deficits related to TBI and other related diseases. Rats with induced TBI improved their performance in a number of tests including cognitive and motor oriented challenges when treated with these ADSCs. This approach provides for numerous new treatment modalities for TBI and related diseases. Furthermore, it can also be used for diagnosing TBI through the use of lncRNAs as biomarkers.

Neuronal Loss in Mice is Significantly Decreased when Treated with Human Adipose Derived Stem Cells (hADSC) Containing or Expressing lncRNAs

Desired Parternships

  • License
  • Sponsored Research
  • Co-Development