A Platform for Selective Intracellular Delivery by the Growth Factor Mediated Macropinocytosis Pathway

Tech ID: 13B158

­Competitive Advantages

  • Targeted drug delivery to tumors
  • Reduced side effects of cancer drugs
  • Made of non-toxic, biodegradable protein
  • Easily synthesized

Summary

Our inventors have created a novel, cargo carrying nanoparticle for the targeted delivery of drugs to cancer cells. The nanoparticle carries a drug to cancer cells, where the drug is released. This reduces the treatment’s toxicity to healthy tissue. The nanoparticle is made of non-toxic protein, and it can be produced at a low cost. The nanoparticle has molecules that bind to receptors on a cancer cell, which makes the cell engulf any nearby drug loaded particles. This novel type of uptake is advantageous because a single nanoparticle can prompt a cell to take up multiple drug payloads. This system has been shown to be a potential treatment of lung cancer, and it may enable the specific delivery of more chemotherapy drugs to treat other varieties of cancer.

Nanoparticle Structure:

Yellow - Targeting Molecule

Red - Drug Payload

ELP - Structure Protein

Desired Partnerships

  • License
  • Sponsored Rsearch
  • Co-Development

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