Silicon Carbide Nanoparticles Fibrous Membrane for Implantable Glucose Sensor Integrated with Chronoamperometric Potentiostat

Tech ID: 20A054

Competitive Advantages

  • Longer durability of sensor
  • Better sensitivity hence, better and more reliable results
  • The SiCNPs-ENFM based sensor has lower power consumption thus making it cost effective

Summary

For a glucose sensor to be an effective part of managing a patient’s diabetes mellitus it needs to be power efficient, compact, portable, sensitive, and have a linear response for targeted levels. Silicon carbide (SiC) is a tested biocompatible material that has been used for clinical studies. 


Our inventors developed an improved Silicon carbide (SiC) based glucose sensor composed of silicon-carbide-nanoparticles (SiCNPs) with a conductive polymer (CP) electrospun-nanofibrous-membrane (ENFM) based glucose sensing electrodes. The glucose sensor is integrated with a complementary metal oxide semiconductor (CMOS) based low-power, low-noise chronoamperometric potentiostat for continuous blood glucose monitoring systems.  SiCNPs with CP ENFM based glucose electrode shows a wide glucose detection range from 0 mM to 11 mM concentration with a shorter response time of less than 4 sec, better sensitivity of 14.27 μA/mM cm2 and the detection limit was 1.8 μM. Thus the SiCNPs-CP-ENFM based glucose sensor provides better sensitivity, better limit of detection, fast response time and durability compared to SCTP electrodes . This glucose monitoring system can be integrated with an analog to digital converter (ADC) and a digital signal processing circuit for development of a compact, portable and wearable device in the form of a system-on-chip (SOC). 

Block diagramof SiCNPs-ENFM based glucose sensor with the integration of chronoamperometric potentiostat.

Desired Partnerships

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