Tetrazole & Coumarin Phosphonate Based Broad-Spectrum Beta-Lactamase Inhibitors

Tech ID: 16A006

Competitive Advantages

  •    Combats bacterial antibiotic resistance to β-Lactamase
  •    Effectively inhibits against the different classes of β-Lactamase
  •    Enhances effectiveness of current β-lactam antibiotics treatments

Summary

Our inventors have discovered tetrazole and coumarin phosphonate based compounds can actively inhibit β-lactamase. Applying a patented pharmaceutical formulation to these compounds, our inventors been able to successfully increase the efficacy of a β-lactam antibiotic or reduce the amount/activity of β-lactamase . These new compounds target the most clinically problematic β-lactamase and can be combined with current treatments on the market today to increase the effectiveness of those treatments. These compounds would be useful in potentiating the action of beta-lactam antibiotics in the treatment of multi-drug resistant bacterial infections.   

 

Tetrazole Based Inhibition Against a Variety of β-Lactamases Classes 

Desired Partnerships

  • License
  • Sponsored Research
  • Co-Development

Technology Transfer
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